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Search Results for " DNA Damage/DNA Repair "

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カタログ番号	製品名	別名	ターゲット
T5399	GeA-69		PARP
	GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays).		PARP
T7318	Elimusertib	BAY-1895344	ATM/ATR
	Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the target...		ATM/ATR
T23974	DDRI-18	DDRI18,DDRI 18	DNA/RNA Synthesis
	DDRI-18 is a novel small molecule inhibitor that regulates the DNA damage response with sensitizing and anticancer activities, inhibits non-homologous end-joining (NHEJ) DNA repair and enhances the cytotoxicity of antica...		DNA/RNA Synthesis
T12682	Emzadirib	CYT-0851,RAD51-IN-2	DNA/RNA Synthesis
	Emzadirib (RAD51-IN-2) is a potent RAD51 inhibitor with potential anticancer activity for the study of DNA damage repair.		DNA/RNA Synthesis
T10406	Tuvusertib	M1774,ATR inhibitor 1	Apoptosis , ATM/ATR , Others , Chk
	Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks...		Apoptosis , ATM/ATR , Others , Chk
T50098	TIQ-A		PARP
	TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in m...		PARP
T3231	Niraparib	MK-4827	Apoptosis , Others , PARP
	Niraparib (MK-4827) is a PARP inhibitor that selectively inhibits PARP1 and PARP2 (IC50=3.8/2.1 nM). Niraparib has antitumor activity, inhibits DNA damage repair, and induces apoptosis.		Apoptosis , Others , PARP
T70873	M3541		Apoptosis , ATM/ATR
	M3541 is a selectively potent and orally active ATM inhibitor with potential antitumor activity.M-3541 inhibits ATM kinase activity and ATM-mediated signaling by binding to ATM.M3541 prevents activation of DNA damage che...		Apoptosis , ATM/ATR
T21320	Methoxyamine HCl	TRC102,TRC 102,Methoxyamine,TRC-102	Others
	Methoxyamine HCl (Methoxyamine) covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis. Methoxyamine is...		Others
T25838	MS0017509	MS-0017509,MS 0017509
	MS0017509 is a DNA damage repair inhibitor.
T25839	MS0019266	MS 0019266,MS-0019266
	MS0019266 is a DNA damage repair inhibitor.
T69931	MFH290
	MFH290 is a novel cysteine (Cys)-directed covalent inhibitor of CDK12/13. MFH290 forms a covalent bond with Cys-1039 of CDK12, exhibits excellent kinome selectivity, inhibits the phosphorylation of serine-2 in the C-term...
T40345	AV-153
	AV-153 is a 1,4-dihydropyridine derivative with antimutagenic properties. It intercalates into DNA at single strand breaks, resulting in reduced DNA damage and stimulation of DNA repair in human cells in vitro. AV-153 al...
T81140	SNM1A-IN-1
	SNM1A-IN-1 (compound 11a) serves as an inhibitor of the DNA damage repair enzyme SNM1A, exhibiting cytotoxic properties [1].
T80207	Tetrapeptide		DNA/RNA Synthesis
	Tetrapeptide, an α-MSH analogue, stimulates melanin production and mitigates DNA damage by attenuating reactive oxidative species generation and augmenting DNA photoproduct repair [1].		DNA/RNA Synthesis
T14282	Amuvatinib hydrochloride	HPK 56 hydrochloride,MP470 hydrochloride	Others
	Amuvatinib hydrochloride (MP470 hydrochloride) is an orally administred multi-targeted tyrosine kinase inhibitor that exhibits strong efficacy against mutant forms of c-Kit, PDGFRα, Flt3, c-Met, and c-Ret, while also act...		Others
T36701	Phosphoramide mustard (cyclohexanamine)
	Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA d...
T78581	Selenocystine		Others
	Selenocystine, a broad-spectrum anticancer agent, effectively induces DNA damage, notably DNA double-strand breaks (DSBs), in HepG2 cells, showcasing significant potential as a therapeutic or adjuvant agent in targeting ...		Others
T63923	ATR-IN-5
	ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair. ATR is a member of the PIKK family, a class of protein kinases involved in genome stabili...
T26981	Ceralasertib formate	Ceralasertib,AZD-6738,AZD 6738,AZD6738
	Ceralasertib is an orally available inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase. Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine prot...
T32189	Iproplatin	JM-9,CHIP,Code name: JM9,JM 9
	Iproplatin is a synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA adducts, resulting in DNA replication failure and cell death. A...
T81249	Ru3		PARP
	Ru3 is a poly(ADP-ribose) polymerase 1 (PARP1) inhibitor that prompts apoptosis in MCF-7 cells through various mechanisms, including DNA damage induction, inhibition of DNA repair, alteration of cell cycle distribution, ...		PARP
T40931	FEN1-IN-2	FEN1-IN-2	Others
	FEN1-IN-2 is a selective and potent inhibitor of flap endonuclease 1 (FEN1), inhibits FEN1 and XPG, has potential anticancer activity, and can be used to study DNA damage repair.		Others
T75335	Ethylenediaminetetraacetic acid dipotassium dihydrate
	Ethylenediaminetetraacetic acid (EDTA) dipotassium dihydrate is anticoagulants, chelating heavy metal and relieve toxicity. Ethylenediaminetetraacetic acid dipotassium dihydrate can damage chromosomes, interfere with the...
T37729	IMP-1700
	IMP-1700 is an inhibitor of bacterial DNA repair.1It potentiates the activity of the quinolone antibiotic ciprofloxacin against methicillin-resistantS. aureus(MRSA) with a combination index value of 0.7. IMP-1700 inhibit...
T81640	NSC15520
	NSC15520, a small-molecule inhibitor of Replication Protein A (RPA), selectively targets the N-terminal DNA binding domain (DBD) of RPA, preventing its interaction with p53 and RAD9. Additionally, NSC15520 impedes the he...
T75021	SZUH280
	SZUH280 is a potent, selective PROTAC (proteolysis targeting chimera) HDAC8 (histone deacetylase 8) degrader, demonstrating a DC50 of 0.58 μM in A549 cells. It induces apoptosis in cancer cells and impedes DNA damage rep...
T73299	APE1-IN-2		Apoptosis
	APE1-IN-2 (compound AP1), a Pt(IV) proagent, selectively targets the essential base excision repair protein apurinic/apyrimidinic endonuclease 1 (APE1). Exhibiting anticancer properties, APE1-IN-2 prompts the intracellul...		Apoptosis
T60649	AV-153 free base
	AV-153 free base is a 1,4-dihydropyridine (1,4-DHP) derivative. AV-153 free base is an antimutagenic with anti-cancer activity. AV-153 free base interacts with cytosine and thymine and has an influence on poly(ADP)ribosy...
T70978	5-Hydroxy Lansoprazole Sulfide
	5-Hydroxy Lansoprazole Sulfide is an inhibitor of fatty acid synthase (FASN). FASN, which is responsible for de-novo synthesis of lipids, has been found to be overexpressed in cancerous tissue. 5-Hydroxy Lansoprazole Sul...
T79134	FEN1-IN-6		FLAP
	FEN1-IN-6 (compound 9) is a potent Flap endonuclease-1 (FEN1, IC50 = 10 nM) inhibitor, crucial for DNA damage repair in mammalian cells, and additionally targets the related endonuclease xeroderma pigmentosum G (XPG) wit...		FLAP
T63555	ATR-IN-6
	ATR-IN-6 is a potent inhibitor of ATR. ATR is a protein kinase that is involved in genome stability and DNA damage repair and is a member of the PIKK family. aTR-IN-6 has shown potential for ATR kinase-mediated diseases ...
T79135	FEN1-IN-7		FLAP
	FEN1-IN-7 (compound 16), a selective Flap endonuclease-1 (FEN1) inhibitor with an IC50 of 18 nM, plays a role in DNA damage repair in mammalian cells. Additionally, it targets the related endonuclease, xeroderma pigmento...		FLAP
T78138	SIC5-6		Others
	SIC5-6 is a potent inhibitor of Separase, a substantial cysteine protease implicated in critical cellular processes such as chromosome segregation during mitosis and meiosis, DNA damage repair, centrosome disengagement a...		Others
T78787	PARP-1/2-IN-2		PARP
	PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC 50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repair and inducing cell cycle arrest and apoptosis. This compound...		PARP
T79689	SIRT6-IN-3		Sirtuin
	SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts apoptosis. It enhances the responsiveness of cancer cells to ...		Sirtuin
T83854	BRC4wt TFA
	BRC4wt, an acetylated peptide originating from the BRC4 repeat within human BRCA2 (1521-1536), acts as an inhibitor of the BRCA2 and RAD51 protein-protein interaction. When linked to the cationic cell-penetrating peptide...
T79647	VEGFR/PARP-IN-1		PARP
	VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively. It impairs DNA damage repair pathways, promotes apoptosis, and halts cells in the G2/M phase. Thi...		PARP
T62540	PARP1/BRD4-IN-2
	PARP1/BRD4-IN-2 is a potent and selective inhibitor of PARP1 (IC50: 197 nM) and BRD4 (IC50: 238 nM).PARP1/BRD4-IN-2 inhibits DNA damage repair, blocks the G0/G1 cell cycle transition, and induces apoptosis.PARP1/BRD4-IN-...

Compounds

Synonym: DDRI18,DDRI 18

Target: DNA/RNA Synthesis

Emzadirib

T12682

Synonym: CYT-0851,RAD51-IN-2

Target: DNA/RNA Synthesis

Tuvusertib

T10406

Synonym: M1774,ATR inhibitor 1

Target: Apoptosis, ATM/ATR, Others, Chk

Target: Apoptosis, Others, PARP

M3541

T70873

Synonym:

Target: Apoptosis, ATM/ATR

Methoxyamine HCl

T21320

Synonym: TRC102,TRC 102,Methoxyamine,TRC-102

Target: Others

MS0017509

T25838

Synonym: MS-0017509,MS 0017509

Target:

MS0019266

T25839

Synonym: MS 0019266,MS-0019266

Target: DNA/RNA Synthesis

Amuvatinib hydrochloride

T14282

Synonym: HPK 56 hydrochloride,MP470 hydrochloride

Target: Others

Phosphoramide mustard (cyclohexanamine)

Synonym: Ceralasertib,AZD-6738,AZD 6738,AZD6738

Target:

Iproplatin

T32189

Synonym: JM-9,CHIP,Code name: JM9,JM 9

Ethylenediaminetetraacetic acid dipotassium dihydrate

5-Hydroxy Lansoprazole Sulfide

カタログ番号	製品名	別名	ターゲット
T4971	5'-DEOXYADENOSINE	5′-dAdo	Endogenous Metabolite
	5'-Deoxyadenosine (5′-dAdo) is an oxidized nucleoside found in the urine of normal subjects. Oxidized nucleosides represent excellent biomarkers for determining the extent of damage in genetic material, which has long be...		Endogenous Metabolite
T10018	1-Methyladenine		Others
	1-Methyladenine is a DNA alkylation product that undergoes damage reversal through oxidative demethylation for repair purposes.		Others

天然物製品

5'-DEOXYADENOSINE

T4971

Synonym: 5′-dAdo

Target: Endogenous Metabolite

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-01188	PARP Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Poly (ADP-ribose) polymerase 1(PRAP1), also known as NAD(+) ADP-ribosyltransferase 1(ADPRT), is a chromatin-associated enzyme that modifies various nuclear proteins by poly(ADP-ribosyl)ation. The ADP-D-ribosyl group of N...
TMPH-01091	CHD1L Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catal...
TMPH-01351	FOxM1 Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in t...
TMPH-01350	FOxM1 Protein, Human, Recombinant (GST)	Human	E. coli
	Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in t...
TMPY-04267	MSH2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	MSH2 is a key DNA mismatch repair protein, which plays an important role in genomic stability. In addition to its DNA repair function, MSH2 serves as a sensor for DNA base analogs-provoked DNA replication errors and bind...
TMPH-01008	PNKP Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini ...
TMPY-02527	P53R2 Protein, Human, Recombinant (His)	Human	E. coli
	Ribonucleoside reductase subunit M2B, also known as RRM2B or p53R2, is an enzyme belonging to the iron-dependent ribonucleotide reductase (RNR) enzyme family which is essential for DNA synthesis. Ribonucleotide reductase...
TMPH-00732	RtcB Protein, E. coli, Recombinant (His)	E. coli	Yeast
	GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends. Also acts as a DNA ligase in case of DNA damage by splici...
TMPH-01882	PARP9 Protein, Human, Recombinant (His)	Human	E. coli
	ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses. Within the complex, enhances DTX3L E3 ligase ...
TMPJ-00457	OGG1 Protein, Human, Recombinant	Human	E. coli
	Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamido...
TMPH-02930	TREX1 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA f...
TMPH-03452	NDPK Protein, S. cerevisiae, Recombinant (His)	Saccharomyces cerevisiae	Yeast
	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Require...
TMPH-02649	FAN1 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficien...
TMPH-00043	Fanconi-associated nuclease 1 Protein, Ailuropoda melanoleuca, Recombinant (His & Myc)	Ailuropoda melanoleuca	E. coli
	Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficien...
TMPH-02201	TREX1 Protein, Human, Recombinant (His & MBP)	Human	Baculovirus
	Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA f...
TMPH-03451	NDPK Protein, S. cerevisiae, Recombinant (E. coli, His)	Saccharomyces cerevisiae	E. coli
	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Require...
TMPH-01239	XPC Protein, Human, Recombinant (His)	Human	E. coli
	Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B an...
TMPH-01880	PARP2 Protein, Human, Recombinant (His)	Human	E. coli
	Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is t...
TMPH-00646	LexA repressor Protein, E. coli, Recombinant (His & SUMO)	E. coli	E. coli
	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA int...
TMPH-01267	RNF13 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair protein...
TMPJ-00033	UBE2B Protein, Human, Recombinant (His)	Human	Human Cells
	Ubiquitin-Conjugating Enzyme E2 B (UBE2B) is a member of the ubiquitin-conjugating enzyme family. UBE2B accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It is shown that UBE2...
TMPJ-00907	GADD45A Protein, Human, Recombinant (His)	Human	E. coli
	Growth Arrest and DNA Damage-Inducible Protein GADD45 α (GADD45A) is a member of the GADD45 family. GADD45A can be induced by UV irradiation, X-rays, growth arrest and alkylating agents, of which can be mediated by some ...
TMPH-02112	SMUG1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The act...
TMPJ-01131	UBE2V2 Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2) is an enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2V2 can be detected in the placenta, colon, liver, and skin. It forms a heterodimer with UBE2N....
TMPY-02495	P19 INK4d Protein, Human, Recombinant (GST)	Human	E. coli
	Cyclin-dependent kinase inhibitor 2D(also known as CDKN2D or p19ink4d), a member of the INK4 family of cyclin-dependent kinase (CDK) inhibitors, negatively regulates the cyclin D-CDK4/6 complexes, which promote G1/S tran...
TMPY-02465	PARP Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	Poly (ADP-ribose) polymerase 1(PRAP1), also known as NAD(+) ADP-ribosyltransferase 1(ADPRT), is a chromatin-associated enzyme that modifies various nuclear proteins by poly(ADP-ribosyl)ation. The ADP-D-ribosyl group of N...
TMPH-00855	RPS3 Protein, Human, Recombinant (His)	Human	E. coli
	Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad spe...
TMPH-01273	TRIP12 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein a...
TMPH-00849	PSMD14 Protein, Human, Recombinant (His & MBP)	Human	Baculovirus
	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded o...
TMPH-02288	UBE2D3 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11)...
TMPH-02286	USP7 Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of M...
TMPY-02228	P53 Protein, Cynomolgus, Recombinant	Cynomolgus	E. coli
	p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and...
TMPJ-00259	TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated	Human	Human Cells
	Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are...
TMPJ-00260	Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	Human Cells
	Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are...
TMPH-01329	FBXW7 Protein, Human, Recombinant (His)	Human	in vitro E. coli expression system
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds pho...
TMPJ-01100	UBE2V1 Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) is a member of the Ubiquitin-conjugating (E2) enzyme family. The E2 catalytic core domain of UBE2V1 lacks an active site cysteine residue, rendering it catalytically inact...
TMPH-02314	XRCC5 Protein, Human, Recombinant (His & MBP)	Human	Baculovirus
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a...
TMPH-02315	XRCC5 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a...
TMPY-04550	JNK2 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Mitogen-activated protein kinase 9 (MAPK9), also well known as c-Jun N-terminal kinase (JNK2), is a member of the MAP kinase subfamily belonging to the protein kinase superfamily. MAPK9 responds to activation by environm...
TMPY-02642	UBE2W Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-conjugating enzymes, also known as UBE2W, E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step of protein ubiquitination. The modification of protein with ubiquitin is an important c...
TMPH-01552	IRF1 Protein, Human, Recombinant (GST & His)	Human	Baculovirus
	Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections,...
TMPY-01713	RbAp48 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Histone-binding protein RBBP4, also known as Retinoblastoma-binding protein 4, Retinoblastoma-binding protein p48, Chromatin assembly factor 1 subunit C, Chromatin assembly factor I p48 subunit, Nucleosome-remodeling fac...
TMPY-05251	RbAp48 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	Histone-binding protein RBBP4, also known as Retinoblastoma-binding protein 4, Retinoblastoma-binding protein p48, Chromatin assembly factor 1 subunit C, Chromatin assembly factor I p48 subunit, Nucleosome-remodeling fac...

PARP Protein, Human, Recombinant (His)

TMPY-01188

Species: Human

Expression System: Baculovirus-Insect Cells

CHD1L Protein, Human, Recombinant (His & SUMO)

TMPH-01091

Species: Human

Expression System: E. coli

FOxM1 Protein, Human, Recombinant (His & Myc & SUMO)

TMPH-01351

Species: Human

Expression System: E. coli

FOxM1 Protein, Human, Recombinant (GST)

TMPH-01350

Species: Human

Expression System: E. coli

MSH2 Protein, Human, Recombinant (His & GST)

TMPY-04267

Species: Human

Expression System: Baculovirus-Insect Cells

PNKP Protein, Human, Recombinant (His & SUMO)

TMPH-01008

Species: Human

Expression System: E. coli

p53R2 Protein, Human, Recombinant (His)

TMPY-02527

Species: Human

Expression System: E. coli

RtcB Protein, E. coli, Recombinant (His)

TMPH-00732

Species: E. coli

Expression System: Yeast

PARP9 Protein, Human, Recombinant (His)

TMPH-01882

Species: Human

Expression System: E. coli

OGG1 Protein, Human, Recombinant

TMPJ-00457

Species: Human

Expression System: E. coli

TREX1 Protein, Mouse, Recombinant (His & Myc)

TMPH-02930

Species: Mouse

Expression System: E. coli

NDPK Protein, S. cerevisiae, Recombinant (His)

TMPH-03452

Species: Saccharomyces cerevisiae

Expression System: Yeast

FAN1 Protein, Mouse, Recombinant (His & Myc)

TMPH-02649

Species: Mouse

Expression System: E. coli

Fanconi-associated nuclease 1 Protein, Ailuropoda melanoleuca, Recombinant (His & Myc)

TMPH-00043

Species: Ailuropoda melanoleuca

Expression System: E. coli

TREX1 Protein, Human, Recombinant (His & MBP)

TMPH-02201

Species: Human

Expression System: Baculovirus

NDPK Protein, S. cerevisiae, Recombinant (E. coli, His)

TMPH-03451

Species: Saccharomyces cerevisiae

Expression System: E. coli

XPC Protein, Human, Recombinant (His)

TMPH-01239

Species: Human

Expression System: E. coli

PARP2 Protein, Human, Recombinant (His)

TMPH-01880

Species: Human

Expression System: E. coli

LexA repressor Protein, E. coli, Recombinant (His & SUMO)

TMPH-00646

Species: E. coli

Expression System: E. coli

RNF13 Protein, Human, Recombinant (His & Myc)

TMPH-01267

Species: Human

Expression System: E. coli

UBE2B Protein, Human, Recombinant (His)

TMPJ-00033

Species: Human

Expression System: Human Cells

GADD45A Protein, Human, Recombinant (His)

TMPJ-00907

Species: Human

Expression System: E. coli

SMUG1 Protein, Human, Recombinant (His & SUMO)

TMPH-02112

Species: Human

Expression System: E. coli

UBE2V2 Protein, Human, Recombinant (His)

TMPJ-01131

Species: Human

Expression System: E. coli

p19 INK4d Protein, Human, Recombinant (GST)

TMPY-02495

Species: Human

Expression System: E. coli

PARP Protein, Mouse, Recombinant (His)

TMPY-02465

Species: Mouse

Expression System: Baculovirus-Insect Cells

RPS3 Protein, Human, Recombinant (His)

TMPH-00855

Species: Human

Expression System: E. coli

TRIP12 Protein, Human, Recombinant (His & Myc)

TMPH-01273

Species: Human

Expression System: E. coli

PSMD14 Protein, Human, Recombinant (His & MBP)

TMPH-00849

Species: Human

Expression System: Baculovirus

UBE2D3 Protein, Human, Recombinant (His & SUMO)

TMPH-02288

Species: Human

Expression System: E. coli

USP7 Protein, Human, Recombinant (His & Myc & SUMO)

TMPH-02286

Species: Human

Expression System: E. coli

p53 Protein, Cynomolgus, Recombinant

TMPY-02228

Species: Cynomolgus

Expression System: E. coli

TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated

TMPJ-00259

Species: Human

Expression System: Human Cells

Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPJ-00260

Species: Human

Expression System: Human Cells

FBXW7 Protein, Human, Recombinant (His)

TMPH-01329

Species: Human

Expression System: in vitro E. coli expression system

UBE2V1 Protein, Human, Recombinant (His)

TMPJ-01100

Species: Human

Expression System: E. coli

XRCC5 Protein, Human, Recombinant (His & MBP)

TMPH-02314

Species: Human

Expression System: Baculovirus

XRCC5 Protein, Human, Recombinant (His & Myc)

TMPH-02315

Species: Human

Expression System: E. coli

JNK2 Protein, Human, Recombinant (His)

TMPY-04550

Species: Human

Expression System: Baculovirus-Insect Cells

UBE2W Protein, Human, Recombinant (His)

TMPY-02642

Species: Human

Expression System: E. coli

IRF1 Protein, Human, Recombinant (GST & His)

TMPH-01552

Species: Human

Expression System: Baculovirus

RbAp48 Protein, Human, Recombinant (His)

TMPY-01713

Species: Human

Expression System: Baculovirus-Insect Cells

RbAp48 Protein, Mouse, Recombinant (His)

TMPY-05251

Species: Mouse

Expression System: Baculovirus-Insect Cells

カタログ番号	製品名
L3900	DNA Damage & Repair Compound Library	937 compounds
	A unique collection of 937 DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS);
L3980	DNA Damage and Repair Compound Library Plus	667 compounds
	Well-chosen 667 compounds with unique structures targeting DNA damage & repair;
L2910	Antioxidant Compound Library	1330 compounds
	Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species (ROS) and a biological system's ability to readily detoxify the reactive intermediates or repair the resulting damage. ...
L3500	Histone Modification Compound Library	480 compounds
	A unique collection of 480 histone modification related compounds for high throughput screening (HTS) and high content screening (HCS);
L8600	Ubiquitination Compound Library	214 compounds
	A unique collection of 214 ubiquitination related small chemicals can be used for high throughput and high content screening；

ライブラリー

DNA Damage & Repair Compound Library

L3900

Compounds: 937

DNA Damage and Repair Compound Library Plus

L3980

Compounds: 667

Antioxidant Compound Library

L2910

Compounds: 1330

Histone Modification Compound Library

L3500

Compounds: 480

Ubiquitination Compound Library

L8600

Compounds: 214